Ability to affect reaction speed when driving motor vehicles or operating other machinery . No information available.
- Ringer's solution instructions for use
- Indications of the drug Ringer's solution
- Pharmacokinetics
- Indications of active substances of Ringer drug
- When is the medication needed?
- Instructions for use
- Limitations and side effects
- What to replace Ringer-Locke's solution?
- Ringer's solution, instructions for use (Method and dosage)
- Overdose
- Description
- Ringer-Locke solution: indications for use in cats
- How Ringer-Locke solution works on the cat's body
- Review: BioPharmGarant Ringer-Locca Injection Solution – The best way to replenish fluids when a cat with chronic renal failure cannot drink
- Composition and mode of action of the solution
- Indications for use in the treatment of cats
- Mechanism of action of Ringer's solution
- Application in practice
- Indications for use
- What contraindications are there
Ringer's solution instructions for use
200 ml – glass bottles (1) – packs of cartons.
200 ml – glass bottles (15) – cardboard boxes.
200 ml – bottles (28) – cartons.
400 ml – glass bottles (1) – cardboard boxes.
400 ml – glass bottles (15) – cardboard boxes.
Rehydrating agent, has a detoxifying effect, restores water and electrolyte composition of blood. When used as a means to replenish the circulating blood volume, due to rapid exit from the bloodstream into the extravasal space, the effect lasts for only 30-40 minutes (therefore, the solution is only suitable for short-term replenishment of circulating blood volume).
Indications of the drug Ringer's solution
Shock, thermal trauma, acute blood loss; dehydration; intestinal fistula; acute intestinal infections (severe course, inability to take rehydrating agents for oral administration); therapeutic plasmapheresis; correction of water and salt balance in acute spilled peritonitis and intestinal obstruction.
Intravenously by drip, at a rate of 60-80 drops/min, or by jetting. The daily dose for adults is 5-20 ml/kg; if necessary it can be increased to 30-50 ml/kg. The daily dose for children is 5-10 ml/kg and the infusion rate is 30-60 drops/min; in case of shock, 20-30 ml/kg should be given initially. The course of treatment is 3-5 days. When therapeutic plasmapheresis is administered in a volume two times the volume of plasma removed (1.2-2.4 liters), in case of severe hypovolemia – in combination with colloidal solutions. The maximum volume of administered solution is 3 l/day.
Pharmacokinetics
Pharmacokinetics of sodium and chlorine ions is the same as that of dietary intake. They are distributed in all organs, tissues and intercellular spaces and are excreted via glomerular filtration by the kidneys. In the tubules there is a significant reabsorption of Na+ and Cl- ions, especially in the Genle loop and distal tubules.
Potassium ions are freely filtered in the glomeruli, but are almost completely reabsorbed in the proximal tubules (excretion is about 100%). The kidneys have a limited ability to maintain the concentration of K + . Therefore, when the concentration of Na + in the distal tubules is high, the loss of K + can be significant and hypokalemia may develop. This accounts for the presence of K + in the remedy.
Calcium ion homeostasis is well controlled by hormones and rarely requires clinical intervention with an IV infusion of the solution.
The drug is not metabolized in the body, it is rapidly excreted by the kidneys (80% within 4 hours, after 12-24 hours it is completely eliminated).
Indications of active substances of Ringer drug
Dehydration and electrolyte balance disorder (thermal burns of 3rd and 4th degree), acute blood loss, correction of water-salt balance in acute spilt peritonitis and intestinal obstruction, acute intestinal infections (severe course, inability to take rehydrating agents for oral administration), hypovolemic shock, therapeutic plasmapheresis, intestinal fistula.
The method of administration and dosing regimen of a particular drug depend on its form of release and other factors. The optimal dosing regimen is determined by the physician. It is necessary to strictly follow the compliance of the dosage form of the particular drug with the indications for use and the dosing regimen.
IV drops or streaming. The volume of injected fluid depends on the type of dehydration, the degree of dehydration and body weight of the patient, the cause of shock.
When is the medication needed?
Ringer-Locke solution in veterinary medicine is used to relieve symptoms of intoxication. When poisoning occurs in adult cats or kittens, weakness, loss of appetite, vomiting and diarrhea are observed. In severe cases, the pet loses vision or bleeds. Indications for the use of Ringer-Lokka fluid for cats:
- intoxication;
- Dehydration after massive blood loss;
- profuse diarrhea;
- Bites of poisonous snakes and insects;
- inflammation of the pleura or peritoneum;
- electrocution;
- burns, frostbite;
- intestinal obstruction;
- period after operations.
Instructions for use
If the pet has symptoms of severe poisoning or dehydration, he will need a Ringer-Locke solution drip. Intravenous drip when intoxicated with poisons should preferably be done in a hospital. If quick help is needed, before a trip to the clinic, the medication should be injected into the pet under the skin. Instructions for use notes that a single dose is 40-50 ml, and the daily dose is 100-150 ml. Kitten's veins are small and constricted, so it is shown to inject the solution subcutaneously. The therapeutic dose is calculated individually based on the weight, age of the animal, complexity of the disease.
Limitations and side effects
The medicine has an identical blood plasma composition, so undesirable symptoms after its use in cats are not observed. Exceeding the dose causes hyperhydration or acidosis. Administration of the drug in such cases is stopped or the dose is reduced. Ringer-Locke solution rapidly increases the content of fluid, so it is prohibited in case of pulmonary or brain edema. The medication is contraindicated if the kitten or adult pet has the following pathologies:
- Kidney dysfunction;
- Difficulty passing urine or lack of urination;
- heart function deficiencies;
- high blood acidity;
- hypovolemia.
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What to replace Ringer-Locke's solution?
The therapeutic liquid can be replaced with its analogues, if necessary. There is a regular solution of Ringer for cats, but it does not contain glucose, which helps the liver to cope with the abundance of toxins. Therefore, this medication is not as effective for poisoning. The following infusion solutions have a similar effect on the cat's body:
If there is no possibility to quickly get to the clinic at the first signs of poisoning in the pet, you need to make an injection yourself in the recommended dosage subcutaneously, but after that the animal should be shown to the veterinarian urgently.
Ringer's solution, instructions for use (Method and dosage)
Ringer's solution is administered intravenously, using a drip or by trickle (if indicated, to provide emergency care). The rate of administration is about 60-80 drops/minute.
For children, the dose is calculated according to the formula 5-10 ml per kg of body weight. The infusion rate is up to 60 drops/minute. In severe cases the dosage can be increased to 30 ml per kg of child weight.
The drip for an adult is calculated as: 20 ml per kg of weight (up to 50 ml per kg).
The duration of treatment depending on the disease and its severity is 3-5 days.
Sometimes it is advisable to use Ringer's solution for cats, dogs and other pets, purchased in a regular pharmacy (not veterinary). In such a case, it is recommended to consult with a veterinarian about the dosage regimen of the drug.
Overdose
Overdose of the remedy is extremely rare. As a rule, it leads to an increase in the frequency and severity of adverse reactions. In such a case, it is recommended to stop administering the solution and adjust the dosage.
When combining the drug with non-steroidal anti-inflammatory drugs, anabolics, corticotropin, vasodilators, androgenic agents, estrogens, mineralocorticoids, ganglioblocators Sodium retention in the body is possible.
Co-administration with cardiac glycosides increases their toxicity.
Combination of the solution with ACE inhibitors ACE INHIBITORS, potassium preparations and diuretics promotes the development of hyperkalemia.
Description
International nonproprietary names: sodium chloride, potassium chloride, calcium chloride, sodium hydrocarbonate, dextrose.
The drug contains 0.8 g of sodium chloride, 0.02 g of potassium chloride, 0.02 g of calcium chloride, 0.02 g of sodium bicarbonate, 0.1 g of glucose as an active ingredient, and water for injections up to 100 ml as an excipient.
By appearance, the drug is a colorless clear liquid.
3.Ringer-Lokka solution is available in glass vials (100, 200 ml) or in bottles of appropriate capacity (200, 250, 400, 500 ml) which are sealed with rubber plugs reinforced with aluminum caps. Each package is supplied with instructions for use.
The shelf life of the drug when observing the storage conditions is 2 years from the date of production. Do not use Ringer-Lokka solution after expiration date.
- Pharmacological properties
- Ringer-Lokka solution belongs to pharmacotherapeutic group of drugs which influence metabolism. Ringer-Locke solution isotonic to animal blood plasma, regulates water-salt and acid-base balance in animal body.
After injection the drug is quickly absorbed from the injection site and distributed in organs and tissues of the animal.
According to State Standard 12.1.007 Ringer-Lokka solution is classified as low hazardous substance (4 class of hazard) according to the degree of impact on animal organism, it does not have irritating effect on tissues.
- Ringer-Locke solution is used in animals for dyspepsia and other diseases accompanied by dehydration and intoxication, blood loss, for washing wounds and eyes.
- There are no contraindications to the use of Ringer-Locke's solution, except for individual hypersensitivity of the animal to the drug components.
- Ringer-Lokka solution is administered subcutaneously or intravenously in the following doses (in ml per animal):
Ringer-Locke solution: indications for use in cats
The drug is a transparent liquid, identical to blood plasma in the composition of electrolytes. The drug is used to treat diseases characterized by loss of tissue fluid, salts, intoxication. Ringer-Locke's solution is used for detoxification, restoration of water-salt balance, washing of eyes or wounds.
The drug is indicated for use in the following cases:
How Ringer-Locke solution works on the cat's body
Ringer-Locke solution contains glucose, which reacts chemically with poisonous substances, converting them into safe compounds. It is not water but salts – Potassium, Sodium and Calcium chlorides – that are needed to remove the toxins from the body. The concentration of electrolytes in Ringer Locke solution is the same as in mammalian blood.
The drug saves a cat's life when blood clotting occurs due to fluid loss. If electrolytes are not administered, there will be sticking of red blood cells, which leads to the formation of blood clots.
Review: BioPharmGarant Ringer-Locca Injection Solution – The best way to replenish fluids when a cat with chronic renal failure cannot drink
Good afternoon!!!
I'm continuing my series of reviews of the medications we use to keep our cat with terminal chronic renal failure (CKF) alive. I described one of the main phosphorus-binding drugs in food (Ipakitini) in my article "Living on Drugs." Now it's turn for such an important drug as Ringer-Locke's solution for injection.
A cat weighing 5 kg needs to drink about 150-200 ml of fluid per day. And a cat with CPN, suffering from polyuria, so much more! But how to give him this fluid when he is nauseated, vomits occasionally and categorically refuses to eat or drink? An attempt to pour water into the mouth with a syringe resulted only in the fact that the vomiting intensified, and the cat began to hammer into the farthest corner. And how much can be poured into the mouth of the resisting and vomiting animal with a 20-cup syringe, that is, the largest possible? A simple calculation shows that such an execution would have to be carried out at least 10 times a day. Who is ready for this, especially when you consider that the water should be given approximately evenly throughout the day and without making allowances for the fact that we all also have to go to work?
We got a solution to this problem from one of the vets. Namely: We have to give subcutaneous drips with Ringer's solution, but Ringer-Locke's is better. Which we bought at a veterinary pharmacy.
I'll tell you right away, buying it is a pain in the ass! It is rarely sold anywhere, and the packaging varies. And yet, do not look for it in the pharmacy for people – I doubt you will find.
Ringer-Lokka solution, contrary to what most people think, differs in composition from Ringer's solution, and even more so from the usual saline solution! It has glucose and a slightly different salt ratio. But, you can do subcutaneous hydration with saline solution as well. But NOT WITH WATER IN NO WAY!
The drip is placed subcutaneously in the area of the withers.Composition and mode of action of the solution
This drug is manufactured by Mosagrogen CJSC. The drug is available as a colorless liquid packed in glass containers or plastic bags of 100, 200, 250 and 400 ml. The principle of its action is based on the following properties:
- removal of toxic substances from the body;
- replenishment of fluid lost as a result of body dehydration;
- restoration of water-salt and acid-base balance;
- Preventing the formation of blood clots;
- Improvement of blood supply to tissues;
- Prevention of decreased blood glucose concentrations.
Indications for use in the treatment of cats
According to the instructions for use, this drug is administered to cats in the following cases:
- dehydration of the body as a result of intoxication with food or medications, uncontrollable vomiting, profuse diarrhea, circulatory disorders, significant blood loss;
- poisoning due to burns, frostbite, shock;
- Inflammatory process in the peritoneum.
Read also: Instructions for use of solution for injection into the ears "Bars": how to use ear drops for the treatment of cats?
Mechanism of action of Ringer's solution
Baking soda has the unique ability to bind many toxins, in particular heavy metals, and to eliminate them from the cat's body in the form of insoluble compounds. An additional plus of Ringer's solution is its harmlessness and absence of irritating components.
Application in practice
If your kitten is poisoned and barely breathes, it is unlikely to find thin veins in the onset of dehydration, so inject Ringer's solution subcutaneously into the cat, directly into the muscle tissues.
Since its composition is close to plasma, the Ringer's solution is immediately absorbed by the body's cells. This helps to save the cat from dehydration.
There is a serious warning for using the solution to dissolve any medications. The salts in it can enter into various compounds with the substances present in the medicine, and it is not clear what can happen to the cat as a result.
The RINGER-LOCKA solution does not contain glucose. Often its use is not so effective in cases of animal poisoning, as it is glucose that helps the liver to eliminate toxic substances.
Indications for use
If the animal has been attacked by a tarantula or bitten by a snake, the poison, entering the bloodstream, causes sticking of red blood cells, which can lead to thrombosis and death. In this case, Ringer's solution should be injected into the cat's vein.
In cases with diarrhea, to quickly saturate the tissues with fluid similar in composition to blood, the drug is used subcutaneously in the form of injections.
Sometimes the animal's life hangs in the balance if pleurisy or peritonitis is diagnosed. The first thing to use is this reliable remedy, which has never failed before.
The dosage of the solution for a cat is calculated according to the weight of the animal and its age. Usually the daily intake is from 100 ml to 150 ml, and a single dose from 40 ml to 50 ml.
What contraindications are there
If the cat is diagnosed with severe tissue swelling or even cerebral edema, it should be understood that administering Ringer's solution will make the situation worse by putting the animal in an even worse condition.
If heart failure is detected, the drug should be excluded so as not to increase blood flow, as the weakened heart muscle may not be able to cope with the increased load.
In cases of severe kidney damage, such as oliguria, when urine escapes slowly, the use of Ringer's solution will also increase swelling and may be fatal.
If the veterinarian diagnoses acidosis, this means there is a sharp change in the acid-base balance in the body, the drug is used with caution. This also applies to cases of hypovolemia, when the blood volume decreases.
Ringer's solution is also used for rescuing other animals. In cases of snake bites, it is a quick help for your dog. The indications for the use of Ringer's solution and contraindications are similar for both cats and dogs.